SWAG视频

PhD. Department of Biochemistry & Molecular Biology, University of Leeds, Leeds, UK

BSc. Department of Biochemical Engineering, East China University of Science and Technology, Shanghai, China

Professor: Western University of Health Sciences, Pomona, CA, USA, 2023 - present

Associate Professor: Western University of Health Sciences, Pomona, CA, USA, 2018 - 2023

Assistant Professor: Western University of Health Sciences, Pomona, CA, USA, 2012 - 2018

Research Assistant Professor, Vanderbilt University, Nashville, TN, USA, 2010 - 2012

Research Fellow, Vanderbilt University, Nashville, TN, USA, 2004 - 2010

Stem cell biology, zebrafish-based drug screening and cancer biology.

My current research mainly focuses on 1) chemical approaches for stem cell/iPS cell cardiomyogenesis, 2) zebrafish-based drug screening, and 3) cancer biology.

By zebrafish-based screening, we have identified a number of small molecules which can modulate key signaling pathways such as BMP, Wnt/尾-catenin and Hedgehog pathways. As these key signaling pathways are involved in stem cell fate decisions and many types of human diseases including cancer, the small molecules that modulate these key pathways may control stem cell differentiation as well as serve leads for cancer drug development.

American Heart Association

American Associaiton for Cancer Resarech

Western University of Health Sciences Research Committee, 2013 ~ Present

Research Advisory Committee, College of Veterinary Medicine,2012 ~ Present

Instructional Resource Committee,College of Veterinary Medicine,2012 ~ Present

Articles

2024

Kaur, G., Xie, C., Dong, C. Najera, J. Nguyen J.T. and*Hao, J (2024) "PDE4D and miR-203 are promising biomarkers for canine atopic dermatitis", Mol Biol Rep 51, 651

Sun, J., Zhong, H., Kang, B., Lum, T., Liu,D., Liang, S.,*Hao, J.and *Guo, R. (2024) "Roles Of PD-L1 In Human Adipose-Derived Mesenchymal Stem Cells Under Inflammatory Microenvironment", Journal of Cellular Biochemistry,25(4):e30544.

2023

Xie, C., Wang, Z., Ba, Y., Aguilar, J., Kyan, A., Zhong, L. and*Hao, J. (2023) 鈥淏MP Signaling Inhibition Overcomes Chemoresistance of Prostate Cancer鈥�, American Journal of Cancer Research,13(9):4073-4086

Hu, X. and*Hao. J.(2023) "Mesenchymal Stem Cells and Their Derivatives for Skin Rejuvenation",International Journal of Biomedical Science 19(1), 26-30

Najera, J. and*Hao, J.(2023) 鈥淩ecent Advance in Mesenchymal Stem Cells Therapy for Atopic Dermatitis鈥�, Journal of Cellular Biochemistry, 124(2):181-187.

2022

Kaur, G., Ramirez, A., Xie, C., Clark, D., Dong C., Maki, C., Ramos, T., Izadyar, F., Lopez Najera, S. O., Harb, J.*Hao, J. (2022) 鈥淎 double-blinded placebo-controlled evaluation of adipose-derived mesenchymal stem cells in treatment of canine atopic dermatitis鈥�. Veterinary Research Communications,46(1):251-260

Meng, X., Wang, H.*Hao, J.(2022) 鈥淩ecent Progress in Drug Development for Fibrodysplasia Ossificans Progressiva鈥�. Molecular and Cellular Biochemistry, 477, 2327鈥�2334, PMID: 35536530.

2021

Xie, C., Lin, PJ. and *Hao, J. (2021) 鈥淓ggmanone Effectively Overcomes Prostate Cancer Cell Chemoresistance鈥�, Biomedicines, 9(5), 538

Gao B, Chen J, Han B, Zhang X, Hao J, Giuliano AE, Cui Y, Cui X.(2021) "Identification of triptonide as a therapeutic agent for triple negative breast cancer treatment". Sci Rep. Jan 28;11(1):2408.

2020

Xie, C., Jiang, W., Lacroix, JJ., *Luo, Y and *Hao, J. (2020) 鈥淚nsight into Molecular Mechanism for Activin A-Induced Bone Morphogenetic Protein Signaling鈥�, Int. J. Mol. Sci. 21(18), 6498

2019

Harb, J., Lin, P.J. and *Hao, J. (2019), 鈥淩ecent Development of Wnt Signaling Pathway Inhibitors for Cancer Therapeutics鈥�, Current Oncology Reports,21(2):12.

Li J. H. and *Hao J. (2019) 鈥淭reatment of Neurodegenerative Diseases with Bioactive Components ofTripterygium wilfordii鈥�, The American Journal of Chinese Medicine 47(04) pp. 769-785

Koury J., Ramirez A., Xie C., Harb J, Dong C., Maki C., Ramos T., Izadyar F., Clark D., Drechsler Y., * Kaur G. and *Hao J. (2019) 鈥淧hosphodiesterase 4D, miR-203 and selected cytokines in the peripheral blood are associated with canine atopic dermatitis鈥�, Plos One14(6):e0218670

2018

Xie, C., Ramirez, A., Wang, Z, Chow, M and *Hao, J (2018) 鈥淎 Simple and Sensitive HPLC-MS/MS Method for Quantification of Eggmanone in Rat Plasma and Its Application to Pharmacokinetics鈥�, Journal of Pharmaceutical and Biomedical Analysis, 153, p37-43.

Li, H., Ha, H., Ding, X., Bae, C., Gazy, N.*Hao, J. and *Zhong, L (2018) 鈥淒MH4, a VEGFR2 Inhibitor, Effectively Suppresses Growth and Invasion of Lung Cancer Cells鈥�,Journal of Applied Biomedicine, 16, 46-50

2017

Botello-Smith WM, Alsamarah A, Chatterjee P, Xie C, Lacroix JJ, *Hao J, *Luo Y. (2017) 鈥淧olymodal allosteric regulation of Type 1 Serine/Threonine Kinase Receptors via a conserved electrostatic lock鈥�. PLoS Comput Biol. 13(8):e1005711.

Zhang X, Tian Y, Yang Y, *Hao J. (2017) 鈥淒evelopment of anticancer agents targeting the Hedgehog signaling鈥�. Cell Mol Life Sci. 74(15):2773-2782.

*Hao, J, Unternaehrer,J, Cui, XJ, Cheng, NH, and Oji, Y (2017) 鈥淩egulation of Stemness in Carcinoma Cells鈥�, Stem Cells International, Article ID 7681769

Taguchi T, Cho JY, Hao J, Nout-Lomas YS, Kang KS, Griffon DJ. (2017) 鈥淚nfluence of hypoxia on the stemness of umbilical cord matrix-derived mesenchymal stem cells cultured on chitosan films鈥�, J Biomed Mater Res B Biomater. 106(2):501-511.

Koury, J., Zhong, L., and *Hao, J.(2017) 鈥淭argeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment鈥�, Stem Cells International, Article ID 2925869

2016

Chinison, J. Aguilar JS., Avalos A., Huang, Y., Wang, Z., Cameron, DJ.,and *Hao, J. (2016) "Triptonide Effectively Inhibits Wnt/尾-Catenin Signaling via C-terminal Transactivation Domain of 尾-catenin". Scientific Reports. 6, 32779; doi: 10.1038/srep32779.

Pang, J., Zuo, Y., Chen, Y., Song, L., Zhu, Q. Yu, J., Shan, C., Cai, Z., Hao, J., Kaplan, FS., Shore, EM., Zhang, K. (2016) 鈥淎CVR1-Fc Suppresses BMP Signaling and Chondro-osseous Differentiation in an in vitro Model of Fibrodysplasia Ossificans Progressiva鈥�, Bone, 92, 29-36.

Wang Z, Ravula R, Shi L, Song Y, Yeung S, Liu M, Lau B, Hao J, Wang J, Lam CW, Chow MS, Huang Y. (2016) 鈥淥vercoming chemoresistance in prostate cancer with Chinese medicine Tripterygium wilfordii via multiple mechanisms鈥�, Oncotarget, doi: 10.18632/oncotarget.10868

*Luo, Y.,Alsamarah, A.,Zhang, K.and *Hao, J. (2016) 鈥淒evelopment of New Therapeutic Agents for Fibrodysplasia Ossificans Progressiva鈥�, Current Molecular Medicine, 16, 4-11

2015

Han, B.C., Qu, Y., Jin, Y.L., Yu, Y., Deng, N., Wawrowsky, K., Zhang, X., Li, N., Bose, S., Liu, Z., Wang, Q., Sakkiah, S., Abrol, R., Kang, S., Zhou, X., Johnson, J., Gao, B., Hao, J., Buttyan, R., Ray, P.S., Hung, M.C., Giuliano, A., Cui, X. (2015) 鈥淔OXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer鈥�, Cell reports, 13, 1-13

Begum, AN., Guoynes, C., Cho, J., Hao, J., Lutfy, K. and Hong Y. (2015) 鈥淩apid generation of sub-type, region-specific neurons and neural networks from human pluripotent stem cell-derived neurospheres鈥�, Stem Cell Research, 15, 731-741

Aguilar, JS., Begum, AN., Alvarez,J., Zhang, X., Hong, Y., and *Hao, J. (2015) 鈥淒irected cardiomyogenesis of human pluripotent stem cells by modulating Wnt/ 尾-catenin and BMP signalling with small molecules鈥�, Biochemical Journal, 469 (2) 235-241

Alsamarah, A., LaCuran,AE., Oelschlaeger, P., *Hao, J. *Luo, Y. (2015) 鈥淯ncovering Molecular Bases Underlying Bone Morphogenetic Protein Receptor Inhibitor Selectivity鈥�, PLoS One, 10(7):e0132221

Zhang, X., *Hao, J. (2015) 鈥淒evelopment of Anticancer Agents Targeting the Wnt/尾-catenin Signaling鈥�, American Journal of Cancer Research, 5(8):2344-2360

Williams CH, Hempel JE, Hao J, Frist AY, Williams MM, Fleming JT, Sulikowski GA, Cooper MK, Chiang C, Hong CC. (2015) 鈥淎n In Vivo Chemical Genetic Screen Identifies Phosphodiesterase 4 as a Pharmacological Target for Hedgehog Signaling Inhibition鈥�, Cell Reports, 11, p43鈥�50

2014

Hao, J*., Lee, R., Chang, A., Fan, J., Labib C., Parsa, C, Orlando, R., Andresen, B. and Huang, Y* (2014) "DMH1, A Small Molecule Inhibitor of BMP Type I Receptors, Suppresses Growth and Invasion of Lung Cancer", PLoS ONE 9(3): e90748.(*corresponding author).

Hao J*., Galindo CL, Tran TL and Sawyer DB*. (2014) "Neuregulin-1尾 induces embryonic stem cell cardiomyogenesis via ErbB3/ErbB2 receptors". Biochemical Journal 458, 335-341, (*corresponding author)

Sheng, CC, Hao, J. and Hong, CC. (2014) 鈥淐hemically Induced Pluripotent Stem Cells (CiPSCs): A Potential Chemical Biological Breakthrough in Reprogramming?鈥� John Wiley & Sons Inc. ISBN: 978-1-118-34959-5.

Hong, CC, Ao, A. andHao, J. (2014) Book: "Chemical Biology in Regenerative Medicine: Bridging Stem Cells and Future Therapies鈥�, John Wiley & Sons Inc.

2013

Han, G.F., Wang, H.T., and *Hao, J. (2013) "Molecular Mechanisms of Embryonic Stem Cell Pluripotency", Pluripotent Stem Cells", INTECH press, ISBN 978-953-51-1192-4(*corresponding author).

Hao, J, Ao, A, Zhou, L, Murphy, CK, Frist, AY, Keel, JJ, Throne, CA,Kim, K, Lee,E and Hong,CC. (2013) "Selective Small Molecule Targeting beta-Catenin Function Discovered by In Vivo Chemical Genetic Screen", Cell Reports, 4, 898-904

Sheng, CC., Zhou, L. and *Hao, J. (2013) 鈥淐urrent Stem Cell Delivery Methods for Myocardial Repair鈥�, BioMed Research International (formerly titled Journal of Biomedicine and Biotechnology), Article ID 547902 (*corresponding author)

2012

Ao A, Hao J, Hopkins CR and Hong CC. (2012) 鈥淒MH1, a Novel BMP Small Molecule Inhibitor, Increases Cardiomyocyte Progenitors and Promotes Cardiac Differentiation in Mouse Embryonic Stem Cells鈥�, PLoS One, 7, e41627

2011

Wiley, DM., Kim, JD, Hao, J., Hong, CC., Bautch, VL., Jin, SK. (2011) 鈥淒istinct signaling pathways regulate sprouting angiogenesis from the dorsal aorta and axial vein鈥� Nature Cell Biology, 13,686鈥�692

*Hao, J,Sawyer, DB., Hatzopoulos, AK and *Hong,CC (2011) 鈥淩ecent progress on chemical biology of pluripotent stem cell: self-renewal, reprogramming and cardiomyogenesis鈥�, Recent Patents on Regenerative Medicine, 1, 263-274,

Ao, A., Hao, J, Hong, CC. (2011) 鈥淩egenerative chemical biology: current challenges and future potentials鈥�, Chemistry & Biology, 18, 413-424

Wang, H., *Hao, J, *Hong, CC. (2011) 鈥淐ardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/尾-catenin signalling鈥�, ACS Chemical Biology, 6, 192鈥�197, (*co-first author and co-corresponding author)

Ao, A, Williams, CH, *Hao, J, *Hong, CC. (2011) 鈥淢odified mouse embryonic stem cell based assay for quantifying cardiogenic induction efficiency鈥�,J Vis Exp., 50, 2656.

Hao, J., Zhou, L., Hong, CC. (2011) 鈥淐hemical biology of pluripotent stem cells: Focus on cardiomyogenesis鈥�, Embryonic Stem Cells - Recent Advances in Pluripotent Stem Cell-Based Regenerative Medicine, INTECH, ISBN: 978-953-307-1985, 51-64

2010 and Before

Hao,J., Daleo, MA and Hong, CC. (2010) 鈥淐rosstalk between mitogen activated protein kinase and phosphoinositide-3 kinase signalling pathways in development and disease鈥�, Systems Biology for Signaling Networks, , Springer, New York, ISBN:978-144-195-7962, 505-529

Hao, J, Williams, C H., Webb, M E., Hong, CC. (2010) 鈥淟arge scale zebrafish-based in vivo small molecule screen鈥�, J. Vis. Exp., 46, 2243

Hao, J, Ho, JN, Lewis, JA, Karim, K, Daniels, RN, Gentry, PR, Hopkins, CR, Lindsley, CW and Hong CC. (2010) 鈥淚n vivo structure activity relationship study of dorsomorphin analogs identifies selective VEGF and BMP inhibitors鈥�,ACS Chemical Biology, 5, 245鈥�253

Hao,J., Daleo MA, Murphy, CK, Yu, PB, Ho, JN, Hu J, Peterson, RT., Hatzopoulos, AK., Hong, CC. (2008) 鈥淒orsomorphin, a Selective Small Molecule Inhibitor of BMP Signaling, Promotes Cardiomyogenesis in Embryonic Stem Cells鈥�, PLoS ONE, 3, e2904

Hao, J., Vann, WF., Hinderlich, S. and Sundaramoorthy, M. (2006)鈥淓limination of 2-keto-3-dexoy-D-glycero-D-galacto-nonulosonic acid 9-phosphate synthase activity from human N-acetylneuraminic acid 9-phosphate synthase by a single mutation鈥�, Biochem. J. 397, 195-201

Hao, J., Balagurumoorthy, P., Sarilla, S. and Sundaramoorthy, M. (2005)鈥淐loning, expression and characterization of sialic acid synthases鈥�, Biochem. Biophys. Res. Comm. 338,1507-1514

Hao, J.and Berry, A. (2004) 鈥淎 thermostable variant of fructose bisphosphate aldolase constructed by directed evolution also shows increased stability in organic solvents鈥�, Protein Eng, Des and Sel. 17, 689-697

Patents

Charles C. Hong, Corey R. Hopkins, Antonis K. Hatzopoulos, Craig W. Lindsley, Jijun Hao. 鈥淐ompounds and methods useful for directing stem cell differentiation鈥�, Patent number: US9040694B1

Charles C. Hong, Charles H. Williams, Jonathan Hempel, T K Feaster, Don H. Rubin, Gary Sulikowski, Jijun Hao, Audrey Frist. 鈥淐ompounds and methods for inhibition of hedgehog signaling and phosphodiesterase鈥�. Patent number: 10329304

Charles C. Hong, Charles H. Williams, Jonathan Hempel, T K Feaster, Don H. Rubin, Gary Sulikowski, Jijun Hao, Audrey Frist. 鈥淐ompounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase鈥�. Patent number: US2017190717A1

Selected Achievements in Small Molecule Development

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