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Ph.D., Physiology, Department of Physiology, Wayne State University School of Medicine, Detroit, MI, 1999

M.S., Computer Science, Wayne State University College of Engineering, Detroit, MI, 2000

B.S., Biology, Hebei University, Baoding, China, 1985

Postdoctoral Research Fellow, Karmanos Cancer Institute, Detroit, MI, 1999-2001

Professor, Department of Biomedical Sciences, COMP, Western University of Health Sciences, 2020-present

Associate Professor, Department of Biomedical Sciences, COMP, Western University of Health Sciences, 2010-2020

Assistant Research Professor, Beckman Research Institute of City of Hope, Duarte, CA, 2007-2010

Assistant Professor, Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY, 2003-2007

Senior Research Associate, Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY, 2001-2003

Physiology of respiratory system (COMP); Physiology of neuroscience system (COMP); Introduction to Biotechnology (GCBS).

Dr. Zhong鈥檚 research interests focus on early cancer detection using autoantibody profiles as biomarkers. His team has developed a novel screening technology for early detection of lung cancer using T7 phage display cDNA libraries and differential biopanning to isolate epitopes reacting with antibodies present specifically in the sera of patients with lung cancer. Using five combined biomarkers, they have achieved both sensitivity and specificity of 91.3 percent for stage I non-small cell lung cancer detection and sensitivity of 82.6 percent and specificity of 87.5 percent for detection of occult (one to five years prior to the radiology diagnosis) non-small cell lung cancer. The results were much more sensitive and specific than the traditional biomarkers for lung cancer.

Research Grant

鈥� NSFC, Zhong (PI), 鈥淐ombined use of novel serologic biomarkers for early detection of non-small cell lung cancer鈥� 2019-2022

鈥� Genetics Biotechnology Inc., Zhong (PI), 鈥淭umor markers for cancer detection and targeted therapy鈥�, 2014-2020

鈥� NSFC, Zhong (PI), 鈥淧rofile of autoantibody signatures for assessing susceptibility of NSCLC among heave smokers鈥�, 2015-2018

鈥� British American Tobacco, Zhong (PI), 鈥淓arly detection of smoking-induced lung cancer鈥�, 2014-2016

鈥� NSFC, Zhong (PI),鈥淧rognosis significance of autoantibody markers in resectable NSCLC鈥�, 2013-2013-2016

鈥� NIH/NCI R21, Zhong (PI), 鈥淧rofiling autoantibodies for early detection of esophageal squamous cell carcinoma鈥�, 2009-2011

鈥� Research subcontract from NCI, Zhong (PI), 鈥淧roteomic approaches to esophageal squamous cell carcinoma diagnostics鈥�, 2008-2010

鈥� NIH R01, Zhong (Co-PI), 鈥淎utoantibodies as marker of NSCLC鈥�, 2003 鈥�2009

鈥� VA Merit Review, Zhong (Co-PI), 鈥淒etection of Tumor Markers in Peripheral Blood of Non-small Cell Lung Cancer Patients鈥�, 2003 鈥�2005

Publications (Selected)

• Jinlin Liu, Shifang Xu, Bin Gao, Meng Yuan, Li Zhong, Rui Guo. (2024) .
• Wenjing Zhang, Russell Uyemura, Kun Zhong, Rui Guo, Li Zhong. (2023) Current Advances and Future Perspectives on Mesenchymal Stem Cell-Derived Extracellular Vesicles in Alzheimer's Disease. Aging and Disease, 2023,10.1436.
• ConglingZhou, Yixue Yin, Jiarui Wang, Ziqi Ren, Luguang Jiao, LiZhong*, Zaifu Yang*.(2023) .
• Shengxian Liang, Haimei Bo, YueZhang, Hongcheng Zhen, Li Zhong. (2023) Alizarin, an Agonist of AHR Receptor, Enhances CYP1A1 Enzyme Activity and Induces Transcriptional Changes in Hepatoma Cell. Molecules, 2023, 28: 7373.
• Xie, C.; Wang, Z.; Ba, Y.; Aguilar, J.; Kyan, A.; Zhong, L.; Hao, J. (2023) BMP signaling inhibition overcomes chemoresistance of prostate cancer. Am J Cancer Res 2023;13(9):4073-4086.
• Zhang, C.; Li,X.; Zhong,L.; Liu, B.; Wang, Y.; Yin,J.; Chen,S.; Liu,Y.; Sun,L.; Zhang,X.; Chen, W. (2023) Assessment of the relationships between invasive endocervical adenocarcinoma and human papillomavirus infection and distribution characteristics in China: According to the new WHO classification criteria in 2020. Cancer Epidemiology, Volume 86, October 2023, 102442.
• Liang,S.;Zhang, Y.; Bo, H.; Duan, W.; Zhong, L. (2023) Insights into the toxicities of UV-328, UV-329, UV-P in HepG2 cells and their roles in AHR-mediated pathway. Ecotoxicology and Environmental Safety, Volume 250, 15 January 2023, 114478.
• Liu, Y.; Yin, J.;Dawsey, S.M.;, Liu, B.; Freedman, N.D.; Cui, J.; Taylor, P.R.; Yin, L.; Abnet, C.A.; Fan, J.; Chen, W.; Zhong, L.; Qiao, Y. (2022) Relationships between serum iron and liver diseases in nutrition intervention trials: A nested case-control study. Cancer Epidemiology, Volume 78, June 2022, 102157.
• Zhao, M.; Lian, A.; Zhong, L., Guo, R. The Regulatory Mechanism Between Lysosomes and Mitochondria in the Etiology of Cardiovascular Diseases. (2022) Acta Physiologica, published online.
• Liang, S.; Liang, G.; Zhang, Y.; Zhan, X., Zhong, L. (2022) Profiling biotoxicities of hexafluoropropylene oxide trimer acid with human embryonic stem cell-based assays. Journal of Environmental Sciences. 116 (2022) 34鈥�42.
• Liang, G.; Sun, J.; Liu, Y.; Liu, D.; Liang, S.; Guo, R.; Zhong, L. (2021) Identification of tumor associated genes using transcriptome analysis. Cancer Research, Volume 81, Issue 13 Supplement, pp. 2312.
• Ly, J.; Chu, Q.; Zhong, L. (2021) Novel therapeutic trends in pneumonia: antibiotics and mesenchymal stem cells. Biomedical Research and Clinical Reviews. 4(5); DOI: 10.31579/2692-9406/082.
• Liu, J.; Zhong, L.; Guo, R. (2021) The role of posttranslational modification and mitochondrial quality control in cardiovascular diseases. Oxidative Medicine and Cellular Longevity, Volume 2021, Article ID 6635836, 15 pages.
• Yang, H.; Heyer, J.; Zhao, H.; Liang, S.; Guo, R.; Zhong, L. (2020) The Potential Role of Cathepsin K in Non-Small Cell Lung Cancer. Molecules 2020, 25, 4136.
• Zhao, H.; Yang, H.; Sun, J.; Liang, G.; Zhao, Q.; Zhang, X.; Liang, S.; Guo, R.; Zhong, L. (2020) Mesenchymal stem cells promote PD-L1 expression in lung cancer cells. Cancer Research, 2020, 80(16):6011.
• Guo R, Yang H, Zhang Y, Li B, Liu X, Zhong L. (2019) The Potential Clinical Role Of Cathepsin K And Autophagy In The Prevention Of Alcoholic Cardiomyopathy. Circulation 140(suppl_1):10585.
• Cao, R, Islamoglu, H, Teskey, G, Gyurjian, K, Abrahem, R, Onajole, O.K, Lun, S, Bishai, W, Kozikowski, A.P, Sathananthan, A, Fraix, M, Zhong L, Stec, J, Venketaraman, V. (2019). The preclinical candidate indole-2 carboxamide improves immune responses to Mycobacterium tuberculosis infection in healthy subjects and individuals with type 2 diabetes. International Microbiology.
• Wang Q, Yang M, Zhang Y, Zhong L, Zheng X. (2019) Novel Combination Oncolytic Adenoviral Gene Therapy Armed with Dm-dNK and CD40L for Breast Cancer. Current Gene Therapy. 19(1)54-65.
• Teskey G , Cao R, Islamoglu H, Medina A, Prasad C, Prasad R, Sathananthan A, Fraix M, Subbian S, Zhong L, Venketaraman V. (2018) The Synergistic Effects of the Glutathione Precursor, NAC and First-Line Antibiotics in the Granulomatous Response Against Mycobacterium tuberculosis. Front Immunol. 9:2069.
• Cao R, Teskey G, Islamoglu H, Abrahem R, Munjal S, Gyurjian K, Zhong L, Venketaraman V. (2018) Characterizing the Effects of Glutathione as an Immunoadjuvant in the Treatment of Tuberculosis. Antimicrob Agents Chemother. 24;62(11).
• Li H, Ha H, Ding X, Bae C, Gazy N, Zhong L. (2018) DMH4, a VEGFR2 Inhibitor, Effectively Suppresses Growth and Invasion of Lung Cancer Cells. Journal of Applied Biomedicine, 16(1): 46-50.
• Cao L, Wang H, Dong X, Zhong L. (2018) Combined analysis of cell-free DNA methylation in plasma for early detection of NSCLC. Cancer Research, 8(13)suppl:4543.

Invited Presentations (Selected)

• Mesenchymal stem cells promote PD-L1 expression in lung cancer cells. American Association for Cancer Research (AACR) annual meeting, Virtual presentation, June 22, 2020.
• Autoantibody profile as biomarkers for early detection of smoking induced lung cancer.China Tobacco Research Institute, Zhengzhou, China. July 26, 2018.
• Novel autoantigens as targets for immunotherapy for NSCLC. Cancer Detection and Treatment Forum, Zhuhai, China.June 20, 2017.
• Emerging biomarkers for early cancer detection.Hebei University Affiliated Hospital, China.Jun 2, 2016.
• Novel biomarkers for non-small cell lung cancer. Hebei University, Baoding, China. June 7, 2015
• Development of blood tumor marker tests for early cancer detection. Hebei Agriculture University College of Life Sciences, China. Jun 11, 2014.
• British American Tobacco in Southampton, UK. Identification of biomarkers for smoking induced lung cancer. May 14, 2013.
• Hebei University College of Life Sciences, Baoding, China. Combined analysis of serological biomarkers for early cancer detection. June 26, 2012
• 7th Early Detection Research Network (EDRN) Scientific Workshop, Combined measurement of serological tumor-associated antigen and autoantibody for detection of esophageal squamous cell carcinoma. September 13-16, 2011, Washington DC.
• International Conference of Wnt Signaling, Organogenesis and Stem Cells, Xiamen, China. 2009.
• American College of Surgeons Oncology Group (ACOSOG) annual meeting in Chicago. Cancer markers in blood samples. 2008.
• Group Research and Development of British American Tobacco Co. Ltd, London, UK. Autoantibodies as Biomarkers for Lung Cancer. 2008.
• The 2nd International Esophageal & Cardiac Cancer Summit, Beijing China. Developing autoantibody tests for detection of ESCC. 2007.
• University of Santiago de Compostela School of Medicine, Santiago, Spain. Autoantibody profile in lung cancer. 2007.