SWAGÊÓƵ

Postdoctoral Fellow, National Institutes of Health, Bethesda, MD,1990-1993

PhD, Budapest University of Technology, Hungary, 1990

BS, Budapest University of Technology, Hungary, 1986

Professor, Department of Biomedical Sciences, COMP, Western University of Health Sciences, 2016-pres

Visiting Scientist, Cedars-Sinai Medical Center, 2016-pres

Visiting Professor, Department of Medicine, UCLA School of Medicine, 2016-2020

Adjunct Professor, Department of Medicine, UCLA School of Medicine, 2013-2016

Associate Professor, Director, Laboratory of Murine Models for Metabolic Disease, Obesity and Diabetes Research Institute, Cedars-Sinai Medical Center, 2007-2016

Associate Professor, Department of Medicine, UCLA School of Medicine, 2007-2013

Assistant Professor, Department of Medicine, UCLA School of Medicine, 2001-2007

Assistant Research Biochemist, Department of Medicine, UCLA, 1998-2001

Research Scientist, Amgen Inc., 1993-1998

TEACHING

Western University of Health Sciences:

Endocrine System (FOM7), COMP, WUHS, 2017-pres

Biochemistry/Genetics (ISOM, FOM3-5), COMP, WUHS, 2016-pres

Courses Chaired/co-Chaired:

Mouse Molecular Genetics (C122/C222), UCLA, 2017-2018

Genetics, Cedars-Sinai PhD Program, 2012-2016

Human Genetics & Genomics (CM256), UCLA, 2003-2016

Additional Lecturing:

Problem-Based Learning, UCLA School of Medicine, 2014

Medical Genetics Training Program, UCLA, 2009-2014

Cardiovascular Biology, Cedars-Sinai PhD Program, 2009-2013

Oncology, Cedars-Sinai PhD Program, 2009-2011

Genetics, Cedars-Sinai PhD Program, 2008

Topics in Genomics (HG210), UCLA, 2007

Mouse Molecular Genetics (CM222), UCLA, 2005

Advanced Human Genetics (HG236), UCLA, 2002

Research in the Peterfy Laboratory focuses on the molecular basis of common metabolic diseases including diabetes, dyslipidemia and coronary artery disease. We use genetic approaches to identify novel determinants and mechanisms responsible for metabolic abnormalities with the goal of providing the foundation for novel therapeutic approaches.

NIH/NIDDK (R01-DK129877), PI: Peterfy/Najjar, Project period: 4/1/22-3/31/26, Novel Molecular Determinants of Insulin Clearance.

NIH/NHLBI (R15-HL154071), PI: Peterfy, Project period: 6/14/21-6/13/25, Lipase Maturation Factor 1 in Hypertriglyceridemia

DOD CDMRP (GRANT13363192), PI: Peterfy, Project period: 7/1/22-6/30/25, Hepatic Insulin Clearance: A Novel Therapeutic Target in Type 2 Diabetes

NIH/NHLBI (R01-HL127155), PI Peterfy, Project period: 7/1/15-4/30/20, Molecular Mechanisms of Lipase Maturation and Secretion

NIH/NHLBI (P01-HL28481), PL Peterfy (PD Lusis), Project period: 7/1/10-6/30/15, Lmf1 in Lipase Expression and Lipid Metabolism

NIH/NHLBI (P01-HL28481), PL Peterfy (PD Lusis), Project period: 2/1/05-1/31/10, Lipase Expression and its Role in the Metabolic Syndrome

American Diabetes Association (1-05-RA-96), PI Peterfy,Project period: 1/1/05-12/31/07, Positional Cloning of a Diabetes-Susceptibility Locus in a Mouse Model of Type 2 Diabetes

American Diabetes Association (023018), PI Peterfy, Project period: 1/1/00-12/31/02, Functional Characterization of a Novel Gene Involved in Insulin Signaling

Talari, N. K., Mattam, U., Kamisnka, D., Sotomayor-Rodriguez, I., Rahman, A. P., Peterfy, M.,Pajukanta, P., Pihlajamäki, J., Krishnan, K. C. (2024) Hepatokine ITIH3 protects against hepatic steatosis by downregulating mitochondrial bioenergetics and de novo lipogenesis. iScience, 27: 109709.

Krishnan, K. C., Vergnes, L., Acin-Perez, R., Stiles, L., Shum, M., Ma, L., Mouisel, E., Pan, C., Moore, T. M.,Peterfy, M., Romanoski, C. E., Reue, K., Bjorkegren, J. L. M., Laakso, M., Liesa, M., Lusis, A. J. (2021) Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2.Nat. Metab., 13: 1552-1568.

Guo, F., Seldin, M.,Peterfy, M, Charugundla, S., Zhou, Z., Lee, S. D., Mouton, A., Rajbhandari, P., Zhang, W., Pellegrini, M., Tontonoz, P., Lusis, A. J., Shih, D. M. (2021) Notum promotes thermogenesis and protects against diet-induced obesity and insulin resistance in mice.Sci. Rep., 11: 16409.

Norheim, F., Krishnan, K. C., Bjellaas, T., Vergnes, L., Pan, C., Parks, B. W., Meng, Y., Lang, J., Ward, J. A., Reue, K., Mehrabian, M., Gundersen, T. E.,Peterfy, M., Dalen, K. T., Drevon, C. A., Hui, S. T., Lusis, A. J., Seldin, M. M. (2020) Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis.Mol. Systems Biol., 17: e9684.

Krishnan, K. C., Floyd, R. R., Sabir, S., Jayasekera, D. W., Leon-Mimila, P. V., Jones, A. E., Cortez, A. A., Shravah, V.,Peterfy, M., Stiles, L., Canizales-Quinteros, S., Huertas-Vazquez, A., Lusis, A. J. (2020): Liver pyruvate kinase promotes NAFLD/NASH in both mice and humans in a sex-specific manner.Cell. Mol. Gastroenterol. Hepat., 14: S2352.

Krishnan, K. C., Sabir, S., Shum, M., Lang, J. M., Floyd, R. R., Acin-Perez, R., Vergnes, L., Seldin, M. M., Fuqua, B. K., Jayasekera, D. W., Nand, S. K., Anum, D. C., Pan, C., Stiles, L.,Peterfy, M., Reue, K., Liesa, M., Lusis, A. J. (2019): Sex-specific metabolic functions of adipose Lipocalin-2.Mol. Metab., 30: 30-47.

Ehrhardt, N., Cui, J., Dagdeviren, S., Saengnipanthkul, S., Goodridge, H. S., Kim, J. K., Lantier, L., Guo, X., Chen, Y. I., Raffel, L. J., Buchanan, T. A., Hsueh, W. A., Rotter, J. I., Goodarzi, M. O., Peterfy, M. (2019) Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans.Obesity27: 434-443.

Peterfy, M., Bedoya, C., Giacobbe, C., Pagano, C., Gentile, M., Rubba, P., Fortunato, G., Di Taranto, M. D. (2018) Characterization of two novel pathogenic variants at compound heterozygous status in Lipase Maturation Factor 1 (LMF1) gene causing severe hypertriglyceridemia.J. Clin. Lipidol. 12: 1253-1259.

Ehrhardt, N., Doche, M. E., Chen, S., Mao, H. Z., Walsh, M. T., Bedoya, C., Guindi, M., Xiong, W., Irudayam, J. I., Iqbal, J., Fuchs, S., French, S. W., Hussain, M. M., Arditi, M., Arumugaswami, V.,Peterfy, M. (2017) Hepatic Tm6sf2 overexpression affects cellular ApoB-trafficking, plasma lipid levels, hepatic steatosis and atherosclerosis.Hum. Mol. Gen. 26: 2719-2731.

Labadzhyan, A., Cui, J.,Peterfy, M., Guo, X., Chen, Y.I., Hsueh, W.A., Rotter, J.I., Goodarzi, M.O. (2016) Insulin clearance is associated with hepatic lipase activity and lipid and adiposity traits in Mexican Americans.PLOS One11: e0166263.

Sha, H., Francisco, A., Ehrhardt, N., Sun, S., Xue, Z., Liu, L., Guber, R., Panhwar, M. S., Hang, S., Xue, B., Brenna, J. T., Kersten, S., Bensadoun, A.,Peterfy, M.*, Long, Q.*, Qi, L.* (2014) The ER-Associated degradation adapter protein Sel1L regulates triglyceride metabolism via lipoprotein lipase.Cell Metab., 20: 458-470. *co-senior authors

Ehrhardt, N., Bedoya, C.,Peterfy, M.(2014) Embryonic viability, lipase deficiency, hypertriglyceridemia and neonatal lethality in a novel LMF1-deficient mouse model.Nutr. Metab. 11: 37-45.

Mao, H. Z., Ehrhardt, N., Bedoya, C., Gomez, J. A., DeZwaan-McCabe, D., Mungrue, I. N., Kaufman, R. J., Rutkowski, D. T.,Peterfy, M.(2014) Lipase Maturation Factor 1 is Induced by Endoplasmic Reticulum Stress Through Atf6α Signaling.J. Biol. Chem. 289: 24417-24427.

Hosseini, M., Ehrhardt, N., Weissglas-Volkov, D., Lai, C-M., Mao, H. Z.., Liao, J., Nikkola, Bensadoun, A., E., Taskinen, M-R., Doolittle, M. H., Pajukanta, P.,Peterfy, M. (2012) Transgenic expression and variation of LMF1 affect LPL activity in mice and humans.Arterioscler. Thromb. Vasc. Biol., 32: 1204-1210.